CHSU Faculty Member Co-Authored Research Article Published in the American Journal of Respiratory Cell and Molecular Biology

California Health Sciences University’s own Assistant Professor of Pharmacology, Vinayak Shenoy, PhD; co-authored a research article titled, “Myeloid-Derived Suppressor Cells are Necessary for Development of Pulmonary Hypertension” that was recently accepted for publication in the American Journal of Respiratory Cell and Molecular Biology.
Pulmonary hypertension (PH) refers to high blood pressure in the blood vessels of the lungs. In this study, Dr. Shenoy along with his collaborator, Dr. Andrew Bryant and his team at the University of Florida demonstrate for the first time that granulocytic myeloid-derived suppressor cells (G-MDSC) play a key role in the development of PH. Furthermore, they observed that the use of a CXCR2 antagonist inhibits accumulation of G-MDSC within the lungs to prevent PH. Thus, this study provides a proof-of-concept for the use of CXCR2 inhibitors as a novel strategy to treat PH.
Coauthors include: Andrew J. Bryant, Chunhua Fu, George Marek, Kyle J. Lorensten, Erica L. Herzog, Mark L. Brantly, Dorina Avram, and Edward W. Scott.
Dr. Shenoy currently teaches Pharmacology I, II and IV at CHSU. He received his Bachelors in Pharmacy from the College of Pharmaceutical Sciences in Manipal, India. He then received his Master’s degree in Pharmacy from the Birla Institute of Technology and Science in Pilani, India before finally earning his PhD at the University of Florida.
His past experiences include: Intern at Torrent Research Center in India, Scientific Officer at Nicholas Piramal Research Center in India, Postdoctoral Fellow at the University of Florida, and Assistant Research Scientist at the University of Florida. Dr. Shenoy has been a part of both the Educational Resources and Awards Committees.
Everyone here at CHSU congratulates Dr. Shenoy for this great achievement. A copy of the article can be downloaded here: http://www.atsjournals.edu/doi/abs/10.1165/rcmb.2017-0214OC